What is Perindopril?
Aceon (Perindopril) is a drug that has a positive vasoconstrictive effect. Its use is shown to people suffering from heart and vascular diseases.
Aceon — a drug produced as tablets of a white hue, with a slight marbling, with a risk. Shape-round, biconvex.
The tablet contains 4 milligrams of perindopril albumin. Of the excipients in the composition there are:
- Magnesium stearate in an amount of 1.6 mg;
- Lactose monohydrate — 120.45 mg;
- Corn starch-13.95 mg;
- Microcrystalline cellulose-20 mg.
Tablets are sold in packages of 7, 10 pieces.
Action was taken
The drug is an effective vasoconstrictor. It reduces post-loading, jamming pressure in the capillaries of the lungs, and resistance in the vessels of the lungs. The use of tablets increases the minute volume of the heart.
The effect is noted after an hour. The maximum amount of the product is reached after 6 hours. The effect lasts for a day.
Aceon is indicated as a drug that reduces the risk of a stroke occurring a second time, complications related to the heart, blood vessels, and dementia. Its positive effect was found in patients with normal blood pressure and hypertension.
It is proved that when using perindopril in an amount of 8 mg. patients have a reduced risk of complications per day. If a person has previously suffered a myocardial infarction, the risk of complications will be about 2.2%.
You can use the tool in combination with amlodipine and indapamide. It is also actively used during monotherapy.
After the tablets are ingested, they are absorbed in the stomach. The bioavailability of the drug is about 67%.
Perindopril binds slightly to plasma proteins — less than 30%. If you take the pills while eating, the metabolism of the substance slows down.
The conclusion from the body of Aceon occurs in the kidneys. If the patient suffers from kidney or heart disease, the excretion of the substance slows down.
Shown to whom
Buy Aceon is recommended in the following cases:
- Prevention of stroke occurred the second time;
- To reduce the risk of heart complications;
- In case of insufficiency of the heart;
- In the case of hypertension.
Dosage and application features
Start taking the drug should be 1-2 mg per day per reception. If there is congestive heart failure, the dose is increased to 2-4 mg per day. Arterial hypertension requires taking 4 mg per day. If for some reason it is not possible to buy Perindopril, you can use Entresto.
If there are problems with the kidneys, the drug regimen is prescribed by a doctor. The method of use and dosage regimen in each case is determined by a specialist. This depends on the form of the issue of funds, other factors. The purpose should be strictly observed.
Improper use of Aceon provokes various side effects:
- Dizziness and headache, sleep disorders, constant drowsiness, confused consciousness;
- Excessive lowering of blood pressure, tachycardia, heart rhythm disorders, myocardial infarction, stroke;
- Constipation, vomiting, impaired taste perception, dry mouth, hepatitis;
- Itching, rash, increased sweating;
- Spasms in the muscles;
- Renal failure;
- Shortness of breath, cough, rhinitis, pneumonia;
- Impaired vision, etc.
To whom the use is contraindicated
The drug can not be used in combination with aliskiren, as well as with drugs containing it, if there is an increased sensitivity to Aceon without a prescription, pregnant women, children under 18 years of age, during lactation.
If there is a violation of the kidneys, it is recommended to set a special intake mode. The doctor will tell you how to take the Aceon.
Combination with other medications
The drug should not be taken together with aliskiren. Otherwise, there may be a deterioration of the kidneys, heart, and blood vessels. Joint use with Estramustine can provoke the appearance of angioedema.
During the use of the drug with drugs containing lithium, the amount of lithium in the blood may increase, and this may provoke toxic poisoning. With insulin, Perindopril should be combined very carefully.
If a person takes diuretics, their blood pressure may drop. To avoid this situation, it is necessary to make up for the loss of fluids or salts in the body before using the product. Also, you can use Perindopril in a lower concentration.
In the case of heart failure, the drug should be used in a lower dosage. It is also worth monitoring how the kidneys work.
The drug can be stored for 2 years.
Keep the product out of the reach of children, in a dry place. It must be protected from the direct rays of the sun. The best temperature regime for storage will be the air temperature no more than 25 degrees Celsius.
Combination with alcohol
During the use of the drug, you should stop drinking alcohol. Alcoholic beverages can harm treatment. They can provoke adverse consequences, namely, acute circulatory failure, loss of consciousness.
The effect of Aceon on the heart and blood pressure is positive. The active substance can cope even with serious pathologies. People who took the drug rated it well. They note that it has a positive effect on overall well-being.
Doctors also speak well of the remedy. However, they also note the possible occurrence of side effects when used incorrectly. The appearance of adverse reactions is from 1 to 10%. However, most of them are quickly eliminated, but it still creates a load on the body. In other words, Aceon should be used as prescribed by a doctor.
The price of the drug varies and can reach about 1 dollar / Euro per tablet. It is implemented in different countries.
The conditions of implementation
Since Aceon is recognized as potent, it is listed in List B. This is why the drug is sold only by prescription.
Separately, it is worth noting the fact that Aceon, which has a rich range of therapeutic effects, is also used to create other means based on it. We are talking about such drugs as plus Indapamide (with a diuretic component, Indapamide Richter (enhanced form), Arginine, Amlodipine.